VEGF 936C>T polymorphism and breast cancer risk: evidence from 5,729 cases and 5,868 controls
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Dongying Gu Meilin Wang
- چاپ و سال / کشور: 2010
Description
Vascular endothelial growth factor (VEGF) is one of the most potent endothelial cell mitogens and plays an important role in angiogenesis. Many published studies have evaluated the association between the VEGF 936C[T polymorphism and breast cancer risk. However, the published findings are inconsistent. In order to derive a more precise estimation of the association, a meta-analysis was performed in this study. A total of eight studies including 5,729 breast cancer cases and 5,868 controls were identified. Overall, no significant associations between the VEGF 936C[T polymorphism and breast cancer risk were found for TT versus CC (OR 0.93, 95% CI 0.73–1.19), CT versus CC (OR 0.91, 95% CI 0.77–1.09), TT/CT versus CC (OR 0.92, 95% CI 0.78–1.08), and TT versus CT/CC (OR 0.96, 95% CI 0.75–1.21). In the subgroup analysis by ethnicity, source of controls, and menopausal status, there was still no significant association detected in any of the genetic models. In summary, our results suggest that the VEGF 936C[T polymorphism may not contribute to breast cancer susceptibility.
Breast Cancer Res Treat (2011) 125:489–493 DOI 10.1007/s10549-010-0991-z Received: 5 May 2010 / Accepted: 11 June 2010 / Published online: 19 June 2010 Springer Science+Business Media, LLC. 2010
