Association between polymorphisms of trinucleotide repeat containing 9 gene and breast cancer risk: evidence from 62,005 subjects
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Min-Bin Chen Xiao-Yang Wu Wei Shen Mu-Xin Wei Chen Li Bin Cai Guo-Qing Tao Pei-Hua Lu
- چاپ و سال / کشور: 2010
Description
Trinucleotide repeat containing 9 (TNRC9) is a gene located at chromosome 16q12. Although of an uncertain function, it is a newly described risk factor for breast cancer. It contains a putative high-mobility group box motif, suggesting its possible role as transcription factor; it has been implicated in breast cancer metastasis. Published studies on the association between TNRC9 polymorphisms and breast cancer risk remain inconclusive, and a meta-analysis is required to verify the association. This pioneering research performed a meta-analysis of eight studies comprising a total of 25,828 cases and 36,177 controls. Significantly elevated breast cancer risk was associated with TNRC9 rs3803662 polymorphism when all studies were pooled in the meta-analysis (T vs. C allele contrast model: OR 1.18, 95% CI 1.09–1.28; TT vs. CC homozygote codominant model: OR 1.26, 95% CI 1.02–1.55; TT vs. CC?CT recessive model: OR 1.23, 95% CI 1.06–1.42). For TNRC9 rs12443621 polymorphism, no significant association was detected in all genetic models. For TNRC9 rs12443621 polymorphism, meanwhile, no significant association was observed in all comparison models. Conclusively, this meta-analysis suggests that TNRC9 rs3803662 polymorphism was significantly correlated with breast cancer risk and the variant T allele of TNRC9 rs3803662 polymorphism is a low-penetrant risk factor for developing breast cancer. There is no significant association between TNRC9 rs12443621 and rs8051542 polymorphisms and risk of breast cancer in current literature.
Breast Cancer Res Treat (2011) 126:177–183 DOI 10.1007/s10549-010-1114-6 Received: 24 July 2010 / Accepted: 3 August 2010 / Published online: 12 August 2010 Springer Science+Business Media, LLC. 2010
