Classification of breast cancer precursors through exhaled breath
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Gregory Shuster Zahava Gallimidi Asnat Heyman Reiss Ekaterina Dovgolevsky Salem Billan Roxolyana Abdah-Bortnyak Abraham Kuten Ahuva Enge
- چاپ و سال / کشور: 2010
Description
Certain benign breast diseases are considered to be precursors of invasive breast cancer. Currently available techniques for diagnosing benign breast conditions lack accuracy. The purpose of this study was to deliver a proofof- concept for a novel method that is based on breath testing to identify breast cancer precursors. Within this context, the authors explored the possibility of using exhaled alveolar breath to identify and distinguish between benign breast conditions, malignant lesions, and healthy states, using a small-scale, case-controlled, cross-sectional clinical trial. Breath samples were collected from 36 volunteers and were analyzed using a tailor-made nanoscale artificial NOSE (NA-NOSE). The NA-NOSE signals were analyzed using two independent methods: (i) principal component analysis, ANOVA and Student’s t-test and (ii) support vector machine analysis to detect statistically significant differences between the sub-populations. The NA-NOSE could distinguish between all studied test populations. Breath testing with a NA-NOSE holds future potential as a cost-effective, fast, and reliable diagnostic test for breast cancer risk factors and precursors, with possible future potential as screening method.
Breast Cancer Res Treat (2011) 126:791–796 DOI 10.1007/s10549-010-1317-x Received: 18 November 2010 / Accepted: 16 December 2010 / Published online: 29 December 2010
