Association of a vascular endothelial growth factor gene 936 C/T polymorphism with breast cancer risk: a meta-analysis
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Dae Sik Yang Kyong Hwa Park Ok Hee Woo Sang Uk Woo Ae-Ree Kim Eun Sook Lee Jae-Bok Lee Yeul Hong Kim Jun Suk Kim Jae Hong Seo
- چاپ و سال / کشور: 2010
Description
Published studies on the association between the vascular endothelial growth factor (VEGF) gene 936 C/T polymorphism and breast cancer risk are inconclusive, and a meta-analysis is required to verify the association. Nine studies, including a total of 4,973 cases and 5,035 controls, were subjected to meta-analysis. When all eligible subjects were pooled for meta-analysis, the CT ? TT genotypes were not associated with a significant decrease in breast cancer risk (odds ratio = 0.87; 95% confidence interval 0.75–1.02; P = 0.087). We also categorized by ethnicity (Caucasian, Asian, or mixed) for subgroup analysis, however, according to this subgroup analysis, we found no significant association between the CT and TT versus CC genotype with breast cancer risk reduction in any of the subgroups. We conclude that the VEGF gene 936 C/T polymorphism does not affect breast cancer risk.
Breast Cancer Res Treat (2011) 125:849–853 DOI 10.1007/s10549-010-1070-1 Received: 17 May 2010 / Accepted: 13 July 2010 / Published online: 21 July 2010
