No evidence for an association of human papillomavirus and breast carcinoma
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Raimundo Geroˆnimo Silva Jr. Benedito Borges da Silva
- چاپ و سال / کشور: 2010
Description
Breast cancer represents a serious public health problem worldwide, for its high incidence, morbidity, mortality, and its high cost treatment. It is known that breast cancer is a multifactorial disease, possessing various risk factors, among which include hormonal factors, genetic and environmental. The role of viruses in breast carcinogenesis is controversial. This study aims to evaluate the expression of HPV 6, 11, 16, and 18 by polymerase chain reaction (PCR) in invasive ductal breast carcinoma. We analyzed 90 women diagnosed with invasive ductal breast carcinoma, of which the extracted DNA was amplified, quantified and tested for DNA subtypes 6, 11, 16, and 18 by PCR. The research carried out in 79 samples of HPV DNA, proved negative. Our study demonstrates no association between the most prevalent types of HPV and breast cancer
Breast Cancer Res Treat (2011) 125:261–264 DOI 10.1007/s10549-010-1129-z Received: 11 August 2010 / Accepted: 13 August 2010 / Published online: 24 August 2010
