CT assessment of breast cancer for pathological involvement of four or more axillary nodes
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Ichiro Ogino Yoshibumi Tayama Mito Arai Tomio Inoue Daisuke Shimizu Takashi Ishikawa
- چاپ و سال / کشور: 2010
Description
Background To predict the likelihood of C4 pathologically positive axillary nodes in breast cancer patients by computed tomography (CT) before neoadjuvant chemotherapy (NAC). Methods Inclusion criteria for the 97 patients reviewed were lymph nodes (LNs) pathologically proved positive with standard level I–II axillary dissection, contrastenhanced CT was performed before surgery, contralateral breast cancer was not present, and NAC was not given before surgery. The size, number, and level of both ipsilateral and contralateral axillary LNs were studied by contrast-enhanced high-resolution CT for pathologically positive LNs in breast cancer patients. Results Level III LN was only detected in ipsilateral axilla of patients with C4 pathologically involved nodes. The number of ipsilateral level I–II LNs is the only factor significantly related to the pathological involvement of C4 axillary nodes. Increasing numbers of contralateral level I–II LNs are significantly related to increasing numbers of ipsilateral level I–II LNs. For the criterion of maximal LN size C5 mm, if contralateral level I–II LNs were negative and the cutoff points for ipsilateral level I–II LNs were 0–2 and C3, the sensitivity and specificity for C4 pathologically involved nodes would be 84.6 and 73.3%. If contralateral I–II LNs were positive, the negative predictive value was 80.0%. Conclusion Level III LN detection in ipsilateral axilla and the number of level I–II LNs in bilateral axilla will be helpful to predict C4 pathologically positive axillary nodes.
Breast Cancer DOI 10.1007/s12282-010-0216-7 Received: 2 April 2010 / Accepted: 2 July 2010 The Japanese Breast Cancer Society 2010
