Retrospective analysis of the effectiveness of first-line antiepileptic drugs for generalized onset and unclassified epileptic seizures in Chinese children
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Ying-Xue Ding & Li-Ping Zou & Ming-Sheng Ma & Ying Wang & Lu-Liang Meng & Fang Fang & Chang-Hong Ding
- چاپ و سال / کشور: 2010
Description
Background and purpose Based on the time until treatment failure, we retrospectively analyzed 389 children to compare the long-term effectiveness of first-line antiepileptic drugs (AEDs) in children with generalized onset or unclassified epileptic seizures. Methods Analyses were based on time until treatment failure and time until remission. Results In terms of time until treatment failure, the failure rates of topiramate and carbamazepine were higher than that of sodium valproate (p<0.05). For time until 1-year remission, sodium valproate was found to be significantly better than either topiramate or carbamazepine (p<0.05). For the subgroup with generalized onset epilepsy, sodium valproate was much better than either topiramate or carbamazepine (p<0.05). No significant differences were found between topiramate and carbamazepine (p=0.319). For unclassified epileptic seizures, no significant differences were found among the three AEDs. Conclusion Sodium valproate should be the drug of choice for patients with children with generalized onset, and no significant differences were found among the three AEDs in unclassified epileptic seizures
Childs Nerv Syst (2011) 27:279–284 DOI 10.1007/s00381-010-1255-2 Received: 23 May 2010 / Accepted: 26 July 2010 / Published online: 6 August 2010
