IDH1 mutations are common in malignant gliomas arising in adolescents: a report from the Children’s Oncology Group
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Ian F. Pollack & Ronald L. Hamilton & Robert W. Sobol & Marina N. Nikiforova & Maureen A. Lyons-Weiler & William A. LaFramboise & Peter C. Burger & Da
- چاپ و سال / کشور: 2010
Description
Purpose Recent studies have demonstrated a high frequency of IDH mutations in adult پgsecondaryپh malignant gliomas arising from preexisting lower grade lesions, often in young adults, but not in پgprimaryپh gliomas. Because pediatric malignant gliomas share some molecular features with adult secondary gliomas, we questioned whether a subset of these tumors also exhibited IDH mutations. Experimental design We examined the frequency of IDH mutations, using real-time polymerase chain reaction and sequencing analysis, in a cohort of 43 pediatric primary malignant gliomas treated on the Childrenپfs Oncology Group ACNS0423 study. The relationship between IDH mutations and other molecular and clinical factors, and outcome, was evaluated. Results IDH1 mutations were observed in 7 of 43 (16.3%) tumors; no IDH2 mutations were observed. A striking age association was apparent in that mutations were noted in 7 of 20 tumors (35%) from children .14 years, but in 0 of 23 (0%) younger children (p=0.0024). No association was observed with clinical factors other than age. One-year event-free survival was 86پ}15% in the IDH-mutated group versus 64پ}8% in the non-mutated group (p=0.03, onesided logrank test). One-year overall survival was 100% in patients with mutations versus 81پ}6.7% in those without mutations (p=0.035, one-sided logrank test). Conclusions IDH1 mutations are common in malignant gliomas in older children, suggesting that a subset of these lesions may be biologically similar to malignant gliomas arising in younger adults and may be associated with a more favorable prognosis.
Childs Nerv Syst (2011) 27:87–94 DOI 10.1007/s00381-010-1264-1 Received: 17 June 2010 / Accepted: 2 August 2010 / Published online: 20 August 2010
