Appraisal of the current staging system for residual medulloblastoma by volumetric analysis
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Dimitris Kombogiorgas , Stephanie Puget , Nathalie Boddaert , Andrew Peet ,Martin English , Kal Natarajan , Jacques Grill , Dominique Couanet ,Christi
- چاپ و سال / کشور: 2011
Description
Aim This study aims to investigate the accuracy of the current staging system of childhood medulloblastoma by using volumetric image analysis on immediate postoperative MRI scans. Material and methods Tumour volume and maximum cross area of residual medulloblastoma were measured on immediate post-operative MR scans of 37 children operated between 1999 and 2005. Results Mean preoperative volume was 32 cm3 (range 4.5– 71.9 cm3). Mean post-operative volume was 3.3 cm3 (range 0–23.3 cm3). At mean follow-up of 50.08 months (range 6– 129), 15 (40%) patients had died. Cut-off limit for residual post-operative tumour volume employed was maximum cross section of 1.5 cm2, which corresponds to volume of 1.376 cm3; 14 patients (38%) had no residual tumour, 7 patients (19%) had less than 1.5 cm2 and 16 patients (43%) had more than 1.5 cm2 residual tumour in its maximum cross section area. In three patients (8.2%) there was mismatch between the measured maximum cross section area and volume. In particular, in two patients, the cross section areas were more than 1.5 cm2 but the residual tumour volumes were less than 1.376 cm3 (the cross section area overestimated the residual volume) and in one case, the cross section area was less than 1.5 cm2 but the residual tumour volume was more than 1.376 cm3 (the cross section area underestimated the residual volume; difference statistically significant, Fisher's exact test, p<0.01). Conclusions It appears that volumetric measurement of residual medulloblastoma on immediate post-operative MRI scans may further improve the accuracy of staging process
Childs Nerv Syst DOI 10.1007/s00381-011-1533-7 Received: 25 June 2011 / Accepted: 12 July 2011
