Glycosylation of mucins present in gastric juice: the effect of helicobacter pylori eradication treatment
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Iwona Radziejewska Ma³gorzata Borzym-Kluczyk Zbigniew Namiot Ewa Stefan´ska
- چاپ و سال / کشور: 2010
Description
It is suggested that gastric mucins, and in particular some specific glycan structures that can act as carbohydrate receptors, are involved in the interactions with Helicobacter pylori adhesins. The main aim of our study was to evaluate glycosylation pattern of glycoproteins of gastric juice before and at the end of eradication therapy. Gastric juices were taken from 13 clinical patients and subjected to analysis. Pooled fractions of the void volume obtained after gel filtration were subjected to ELISA tests. To assess the relative amounts of carbohydrate structures, lectins and monoclonal antibodies were used. Changes in the level of MUC 1 and MUC 5AC mucins and of carbohydrate structures, which are suggested to be receptors for Helicobacter pylori adhesins, were observed by the end of the eradication treatment. Our results support the idea about the involvement of MUC 5AC and MUC 1 with some specific sugar structures in the mechanism of Helicobacter pylori infection.
Clin Exp Med (2011) 11:81–88 DOI 10.1007/s10238-010-0113-6 Received: 31 March 2010 / Accepted: 27 September 2010 / Published online: 17 October 2010
