Effect of IL-1b and TNF-a polymorphisms on the prognosis and survival of gastric cancer patients
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Tomomitsu Tahara Tomoyuki Shibata Masakatsu Nakamura Hiromi Yamashita Daisuke Yoshioka Masaaki Okubo Joh Yonemura Yoshiteru Maeda Naok
- چاپ و سال / کشور: 2010
Description
So far, a number of association studies have focused on the effect of polymorphisms in IL-1b and TNF-a genes on the susceptibility to gastric cancer (GC). Here, we evaluate the possible association between common polymorphisms in the IL-1b and TNF-a genes with various clinicopathological characteristics, including overall survival of GC patients. Restriction fragment length polymorphism analysis was performed for IL-1b-31(T[C) and IL-1b-511(C[T) and TNF-a-857 (C[T) polymorphisms in 130 GC patients. IL-1b-31CC and IL-1b-511TT genotypes held a significantly lower risk of lymphatic invasion (IL-1b-31CC vs. others: adjusted OR = 0.39, 95% CI = 0.15–0.96, P = 0.04, IL-1b-511TT vs. others: adjusted OR = 0.23, 95% CI = 0.08–0.67, P = 0.007). The IL-1b- 31CC and IL-1b-511TT genotypes were weakly associated with reduced risk of venous invasion (IL-1b-31CC vs. others: adjusted OR = 0.35, 95% CI = 0.12–1.05, P = 0.06, IL-1b-511TT vs. others: adjusted OR = 0.32, 95% CI = 0.08–1.20, P = 0.09). The IL-1b-511TT genotype was also weakly associated with reduced risk of lymph node metastasis (IL-1b-511TT vs. others: adjusted OR = 0.42, 95% CI = 0.17–1.04, P = 0.06). When the TNF-a-857CT and TNF-a-857-TT genotypes were considered as T carrier, the patients with TNF-a-857T carrier showed significantly better overall survival than patients with CC genotype (P = 0.011). GC patients who have both IL-1b-31 CC and IL-1b-511 TT genotypes and have at least one of protective genotypes (IL-1b-31 CC, IL-1b-511 TT, TNF-a-857 T carrier) were also associated with better prognostic factors, such as lymphatic and venous invasion better survival. IL-1b-31CC, IL-1b-511TT genotype, and TNF-a-857T carrier may have protective effect against GC progression.
Clin Exp Med DOI 10.1007/s10238-010-0129-y Received: 27 July 2010 / Accepted: 22 December 2010
