Tetraspanins and tumor progression
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Mekel M. Richardson Lisa K. Jennings Xin A. Zhang
- چاپ و سال / کشور: 2010
Description
Transmembrane protein tetraspanins either promote or suppress tumor invasion and metastasis. Their effects on tumor progression depend on the multimolecular transmembrane complex called tetraspanin-enriched microdomain (TEM) and are attributed to the alterations in the (1) motogenic and mitogenic behaviors and/or (2) microenvironmental interactions of tumor cells. As the modifiers of cell membrane structure and function, tetraspanins have emerged as diagnostic and prognostic markers and therapeutic targets for tumor progressio
Clin Exp Metastasis (2011) 28:261–270 DOI 10.1007/s10585-010-9365-5 Received: 29 August 2010 / Accepted: 30 November 2010 / Published online: 24 December 2010
