Expression and significance of HER family receptors in neuroblastic tumors
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Ewa Izycka-Swieszewska Agnieszka Wozniak Elzbieta Drozynska Jacek Kot Wieslawa Grajkowska Teresa Klepacka Danuta Perek Sylwia Koltan E
- چاپ و سال / کشور: 2011
Description
HER receptor family plays an important role in normal embryonic development and is involved in pathogenesis and progression of some types of cancer. Neuroblastic tumors (NT) are common pediatric neoplasms with a poor outcome in a significant number of patients. The biological and prognostic role of HER family in NT is not well established. In the current study we evaluated HER1–4 receptors expression, their prognostic significance and clinicopathological correlations in a series of 103 NTs by immunohistochemical assessment of HER1–4 expression and FISH analysis of EGFR and HER2 copy number status. HER receptors are commonly expressed in NT but it was not due to EGFR or HER2 amplification. EGFR, HER2 and HER4 show correlation with tumor histology. It seems that these receptors take part in neuroblastic cell differentiation and Schwannian stroma development. EGFR and HER2 positivity are more frequently found in favorable histological risk group of tumours (P = 0.004 and P = 0.01 respectively) while high expression of HER4 is significantly more often found in patients with metastatic disease (P = 0.03). Moreover tumors with HER2 polysomy were more often found in children B18 months, with localized disease, and favorable histological group. Our study showed that the role of HER family members in NT biology is interrelated and complex but their expression level may present a novel prognostic factor for NT patients outcome.
Clin Exp Metastasis (2011) 28:271–282 DOI 10.1007/s10585-010-9369- Received: 18 July 2010 / Accepted: 16 December 2010 / Published online: 4 January 2011
