The association of plasma prorenin level with an oxidative stress marker, 8-OHdG, in nondiabetic hemodialysis patients
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Yoshiyuki Morishita Shiho Hanawa Takuya Miki Taro Sugase Yasuhiro Sugaya Junko Chinda Osamu Iimura Sadao Tsunematsu Kenichi Ishibashi
- چاپ و سال / کشور: 2011
Description
Background Circulating prorenin contributes to the pathogenesis of tissue damage leading to cardiovascular disease (CVD) in hypertension and diabetic mellitus (DM) by activating the tissue renin–angiotensin–aldosterone (RAS) system; however, little is known about its roles in hemodialysis (HD) patients. Methods We evaluated plasma prorenin level and prorenin receptor [(P)RR] expression in peripheral blood mononuclear cells (PBMCs) in 49 nondiabetic HD (non- DM-HD) patients. Then we investigated the association between plasma prorenin level or (P)RR expression level in PBMCs and CVD-predictive biomarkers. Results The plasma prorenin level increased in non-DMHD patients [147.1 ± 118.9 pg/ml (standard value \100 pg/ml)]. The (P)RR mRNA expression level in PBMCs also increased 1.41 ± 0.39-fold in non-DM-HD patients compared with that in healthy control subjects (p\0.001). Although plasma prorenin level did not correlate with plasma BNP level and plasma high-sensitivity C-reactive protein level, it significantly correlated with plasma 8-hydroxydeoxyguanosine (8-OHdG) level (r = 0.535, p\0.001). The plasma prorenin level did not correlate with plasma renin activity (PRA), plasma angiotensin I (AT I) level, plasma angiotensin II (AT II) level and plasma aldosterone (Ald) level. PRA, plasma AT I level, plasma AT II level and plasma Ald level did not correlate with the level of any CVD predictive biomarker. (P)RR expression level in PBMCs did not correlate with the level of any CVD predictive biomarker. Conclusions The plasma prorenin level and (P)RR expression level in PBMCs increased, and the plasma prorenin level was associated with plasma 8-OHdG level independent of circulating RAS in non-DM-HD patients.
Clin Exp Nephrol (2011) 15:398–404 Received: 18 August 2010 / Accepted: 20 December 2010 / Published online: 15 January 2011 Japanese Society of Nephrology 2011
