Diffuse alveolar hemorrhage in lupus nephritis complicated by microscopic polyangiitis
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Motohide Isono Hisazumi Araki Takao Haitani Yoshikata Morita Mako Yasuda Noriko Kato Koji Urasaki Yoshinori Tsujimura
- چاپ و سال / کشور: 2011
Description
Diffuse alveolar hemorrhage (DAH) is a rare but fatal complication in patients with systemic lupus erythematosus (SLE). We describe a case of a 74-year-old woman who presented with DAH as an initial presentation of SLE. She also had microscopic polyangiitis clinically manifesting as crescentic glomerulonephritis and purpura with positive myeloperoxidase (MPO)-antineutrophil cytoplasmic antibodies (ANCA). The patient transiently improved when treated with plasma exchange and methylprednisolone pulse therapy; however, she died of recurrent pulmonary hemorrhage and concurrent cryptococcal pneumonia. This case indicates that MPO-ANCA is associated with severe organ involvement such as pulmonary hemorrhage and crescentic glomerulonephritis in SLE.
Clin Exp Nephrol (2011) 15:294–298 Received: 16 July 2010 / Accepted: 8 December 2010 / Published online: 12 January 2011 Japanese Society of Nephrology 2010
