A rare case of malignant-phase hypertension with pulmonary alveolar hemorrhage
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Kazutaka Nanba Kensei Yahata Yuko Kikuchi Chinatsu Okamoto Koichi Seta Akira Sugawara
- چاپ و سال / کشور: 2011
Description
Malignant-phase hypertension is characterized clinically by severe accelerating hypertension with neuroretinopathy or papilledema and by evidence of renal damage. A Japanese male in his early thirties presented with hemoptysis and general fatigue. He had a 5-year history of hypertension, but had not received any treatment. His blood pressure was 290/150 mmHg and his serum creatinine level was 8.24 mg/dL. Chest X-rays and computed tomography scans of the chest revealed a pulmonary alveolar hemorrhage. He was suspected of having vasculitis syndrome or Goodpasture’s syndrome, but his renal biopsy specimen showed malignant nephrosclerosis. Myeloperoxidase antineutrophil cytoplasmic antibody (ANCA), proteinase-3 ANCA and antiglomerular basement membrane antibody were negative. He was treated with a calcium antagonist and a b-blocker, followed by an angiotensin-converting enzyme inhibitor. After the administration of the b-blocker, his blood pressure decreased and his renal function gradually improved. This is a rare case of malignant-phase hypertension with pulmonary alveolar hemorrhage; this condition should be considered in the differential diagnosis in order to avoid unnecessary treatment such as immunosuppressive therapy.
Clin Exp Nephrol (2011) 15:303–307, Received: 20 December 2009 / Accepted: 20 December 2010 / Published online: 1 February 2011 Japanese Society of Nephrology 2011
