Significance of past history of renal failure for the detection of high-risk individuals for cardiovascular and end-stage renal disease: analysis of data from a nationwide health checkup
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Kazunobu Ichikawa Tsuneo Konta Ami Ikeda Shouichi Fujimoto Kunitoshi Iseki Toshiki Moriyama Kunihiro Yamagata Kazuhiko Tsuruya Hideaki
- چاپ و سال / کشور: 2011
Description
Background Clinical information regarding risk factors may be helpful in the detection of various diseases. This cross-sectional study examined the characteristics of subjects with past history of renal failure, and assessed whether this information would be useful for the efficient detection of high-risk individuals for chronic kidney disease (CKD) and cardiovascular disease (CVD) at health checkup. Methods This study utilized data from a nationwide health checkup, ‘‘The Specific Health Check and Guidance in Japan,’’ and data for 250,130 adult subjects were analyzed. Subjects with self-reported history of renal failure and receiving dialysis therapy were defined as having a history of renal failure. Results Among total participants, there were 1,400 (0.6%) with a history of renal failure. The prevalence of a history of renal failure was higher in subjects with CKD than in those without CKD (1.5 vs. 0.3%, P\0.001) and increased with progression of the stage of CKD (0.9–43.5%). Subjects with a history of renal failure had a reduced estimated glomerular filtration rate (44.6 ± 20.3 ml/min/1.73 m2) and a higher prevalence of CKD (50.5%) and CVD (31.9%), compared with subjects with hypertension, diabetes or metabolic syndrome. Multivariate logistic regression analysis showed an independent association between a history of CVD and renal failure (odds ratio 3.68, 95% confidence interval 3.26–4.15), after adjustment for confounding factors. Conclusions A history of renal failure was strongly associated with advanced CKD and CVD. Information regarding history of renal failure could be utilized to efficiently detect high-risk individuals at health checkup.
Clin Exp Nephrol DOI 10.1007/s10157-011-0509-y Received: 10 May 2011 / Accepted: 18 July 2011
