Measurements of serum cystatin C concentrations underestimate renal dysfunction in pediatric patients with chronic kidney disease
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Osamu Uemura Katsumi Ushijima Takuhito Nagai Takuji Yamada Satoshi Yamakawa Yoshiko Hibi Hideki Hayakawa Yayoi Nabeta Yoshiko Shinkai
- چاپ و سال / کشور: 2011
Description
Background In our clinical experience, cystatin C (CysC) concentrations are not as high as expected in patients with chronic kidney disease (CKD) and high-stage renal dysfunction. We therefore investigated whether measurements of serum CysC result in an underestimation of renal dysfunction in pediatric patients with CKD. Methods Glomerular filtration rate (GFR) was estimated from serum creatinine (Cr) concentration, using the equation Cr-GFR (%) = [0.30 9 body length (m)/serum Cr] 9 100; and from serum CysC concentration, using the equation Cys-GFR (%) = (0.70/serum CysC) 9 100. We investigated the relationship between GFR estimated by these 2 equations. Patients aged 2–12 years were assorted into 5 groups, based on GFR-Cr categories of\12.5, C12.5 to\25, C25 to\50, C50 to\75, and C75%, and GFRCysC/ GFR-Cr ratios were compared in these 5 groups. Results The median GFR-CysC/GFR-Cr ratio in groups of patients with GFR-Cr of\12.5, C12.5 to\25, C25 to \50, C50 to\75, and C75% were 2.28, 1.48, 1.22, 1.18 and 0.98, respectively, with statistically significant differences between any two groups (p\0.001). Conclusion Measurements of serum CysC concentrations lead to underestimation of renal dysfunction in pediatric patients with CKD.
Clin Exp Nephrol Received: 24 January 2011 / Accepted: 24 March 2011 Japanese Society of Nephrology 2011
