Obesity and chronic kidney disease in patients with chronic heart failure: an insight from the China Heart Survey
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Hao Liu Hong Shi Jinming Yu Fang Chen Qingwu Jiang Dayi Hu
- چاپ و سال / کشور: 2011
Description
Background Obesity and decreased kidney function have been shown to be prevalent in Western patients with heart failure; however, whether this phenomenon exists in Chinese patients with chronic heart failure (CHF) is not known. Methods and results One thousand and nine patients with CHF from the China Heart Survey were assessed. The prevalence of chronic kidney disease (CKD) was 34.2%, and there was a stepwise increase in the prevalence of CKD with New York Heart Association (NYHA) classes (P\0.001). Moreover, patients with CKD had a significantly elevated risk for developing severe extent of CHF (OR = 1.69, 95% CI: 1.27–2.24, P\0.001). The prevalence of obesity and central obesity was 35.7% and 62.5%, respectively. Notably, there was a downward trend in the prevalence of obesity with advanced NYHA classes (trend test, P = 0.003). Multivariate analysis further supported the finding that obesity, but not central obesity, was inversely associated with the extent of CHF (OR = 0.72, 95% CI: 0.55–0.94, P = 0.017). Conclusions Renal dysfunction is common in Chinese patients with CHF and is independently associated with advanced NYHA classes. Obesity was inversely associated with the extent of CHF, which further supports the notion that obesity confers improved prognosis in patients with heart failure.
Clin Exp Nephro lReceived: 2 November 2010 / Accepted: 23 March 2011 Japanese Society of Nephrology 2011
