Periodontal treatment decreases plasma oxidized LDL level and oxidative stress
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Naofumi Tamaki & Takaaki Tomofuji & Daisuke Ekuni & Reiko Yamanaka & Manabu Morita
- چاپ و سال / کشور: 2010
Description
Periodontitis induces excessive production of reactive oxygen species in periodontal lesions. This may impair circulating pro-oxidant/anti-oxidant balance and induce the oxidation of low-density lipoprotein (LDL) in blood. The purpose of this study was to monitor circulating oxidized LDL and oxidative stress in subjects with chronic periodontitis following non-surgical periodontal treatment. Plasma levels of oxidized LDL and oxidative stress in 22 otherwise healthy non-smokers with chronic periodontitis (mean age 44.0 years) were measured at baseline and at 1 and 2 months after non-surgical periodontal treatment. At baseline, chronic periodontitis patients had higher plasma levels of oxidized LDL and oxidative stress than healthy subjects (p<0.001). Periodontal treatment was associated with a significant reduction in plasma levels of oxidized LDL (oxLDL) (p<0.001) and oxidative stress (p<0.001). At 2 months after periodontal treatment, the degree of change in the oxLDL was positively correlated with that in the oxidative stress (r=0.593, p=0.004). These observations indicate that periodontitis patients showed higher levels of circulating oxLDL and oxidative stress than healthy subjects. In addition, improved oral hygiene and non-surgical periodontal treatment were effective in decreasing oxLDL, which was positively associated with a reduction in circulating oxidative stress.
Clin Oral Invest DOI 10.1007/s00784-010-0458-y Received: 18 February 2010 / Accepted: 29 July 2010
