Salivary bone turnover markers in healthy pre- and postmenopausal women: daily and seasonal rhythm
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Gretel G. Pellegrini & Macarena M. S. Gonzales Chaves & Maria A. Fajardo & Graciela M. Ponce & Gloria I. Toyos & Fima Lifshitz & Silvia M. Friedman &
- چاپ و سال / کشور: 2011
Description
No studies had investigated circadian and circannual rhythms of bone biomarkers in whole saliva. We evaluated the salivary daily and seasonal rhythm of carboxy-terminal telopeptide of type I collagen (CTX) and bone alkaline phosphatase (b-ALP). Forty clinical and oral healthy ambulatory pre- and postmenopausal women from two southern Argentine cities: Comodoro Rivadavia (latitude 45؛ S) and Ushuaia (latitude 54؛ S) were included in the study. CTX levels were evaluated in serum, urine, and saliva, and b-ALP levels were measured in serum and saliva. In both groups of women, salivary CTX showed a maximum percentage of change early in the morning (80%) and a minimum in the late afternoon (45%), similarly to the pattern observed in urinary samples. No daily rhythm was observed in serum or salivary b-ALP. 25-Hydroxyvitamin D levels decreased in winter vs. summer (p<0.01) without differences between the two studied groups. Conversely, parathormone reached higher levels in winter (p<0.05) which induced a slight non-significant increment in salivary CTX and b-ALP levels. The results showed that, as in serum and urinary samples, salivary CTX exhibits daily and a slight seasonal rhythmicity. Whole non-stimulated saliva is a useful tool to detect several oral and systemic diseases because it has important advantages compared to serum and urinary samples. Then, it may also be a promising sample to test changes in bone metabolism contributing to diagnose and to monitor the therapy of several metabolic bone diseases.
Clin Oral Invest DOI 10.1007/s00784-011-0538-7 Received: 30 August 2010 / Accepted: 1 March 2011
