Right ventricular function in grown-up patients after correction of congenital right heart disease
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Julia Lemmer Grit Heise Axel Rentzsch Petra Boettler Titus Kuehne Karl Otto Dubowy Brigitte Peters Bjoern Lemmer Alfred Hager Brigitte
- چاپ و سال / کشور: 2010
Description
Aims We investigated whether a correlation exists between biomarkers of the neurohumoral system and clinical markers in grown-up patients with congenital heart disease (GUCH) and right ventricular function. Methods and results Prospective, cross-sectional, multicenter study of 104 GUCH patients (median) 16 years (range 6–43 years) after corrective surgery with RV pressure and/or volume overload and 54 healthy controls. Clinical, functional, and laboratory parameters were assessed. Natriuretic peptide levels were significantly increased in GUCH patients (NTproBNP 101 vs. 25 pg/ml, p\0.001), but we observed no differences in norepinephrine, aldosterone, angiotensin II and Endothelin-1 levels. NTproBNP correlated significantly with clinical markers such as NYHA classification, prolonged QRS duration and reduced exercise capacity (VO2 peak) (all p\0.001), as well as self-reported quality of life (p\0.001). MRI and echocardiography derived RV volumes were elevated and ejection fraction reduced in the patients (both p\0.001). Tissue Doppler parameter showed significantly restricted ventricular longitudinal systolic function (longitudinal tricuspid valve movement, 1.7 vs. 2.3 cm, p\0.001), suggesting stiffness and reduced RV compliance. Conclusion In conclusion, grown-up patients with congenital right heart disease NTproBNP correlates well with various clinical markers of RV failure, such as prolongation of QRS duration, exercise capacity, echocardiography and MRI parameters, and quality of life.
Clin Res Cardiol (2011) 100:289–296 DOI 10.1007/s00392-010-0241-8 Received: 3 February 2010 / Accepted: 1 October 2010 / Published online: 28 October 2010
