Transforming growth factor beta 1 (TGF-beta 1) in atrial fibrillation and acute congestive heart failure
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Michael Behnes Ursula Hoffmann Siegfried Lang Christel Weiss Parviz Ahmad-Nejad Michael Neumaier Martin Borggrefe Martina Brueckmann
- چاپ و سال / کشور: 2010
Description
Purpose Atrial fibrillation (AF) and acute congestive heart failure (aCHF) are characterized by an adverse cardiac remodeling. Arrhythmogenic or structural remodeling can be caused by interstitial fibrosis. Transforming growth factor beta 1 (TGF-beta 1) represents a central regulator of cardiac fibrosis. This study investigates serum levels of TGF-beta 1 in patients with AF and aCHF. Methods 401 patients presenting with symptoms of dyspnea or peripheral edema were prospectively enrolled. Blood samples for measurement of TGF-beta 1 (R&D Systems, Inc.) and amino-terminal pro-brain natriuretic peptide (NT-proBNP) (DadeBehring ltd.) were collected after the initial clinical evaluation. Results Median TGF-beta 1 levels were lower in patients with AF (21.0 ng/ml, interquartile range (IR) 15.4–27.6 ng/ ml, n = 107) compared to those without (25.0 ng/ml, IR 18.5–31.6 ng/ml, n = 294) (p = 0.009). Patients with aCHF had lower TGF-beta 1 levels (median 22.0 ng/ml, IR 15.6–27.1 ng/ml, n = 122) than those without (median 24.9 ng/ml, IR 18.1–31.9 ng/ml, n = 279) (p = 0.0005). In logistic regression models TGF-beta 1 was still associated with AF (odds ratio (OR) 3.00, 95% CI 1.37–6.61, p = 0.0001) and aCHF (OR 3.98, 95% CI 1.55–10.19, p = 0.004). TGF-beta 1 inversely correlated with left atrial diameter (r = -0.30, p = 0.007) and NT-proBNP (r = -0.14, p = 0.007). Conclusions Low serum levels of TGF-beta 1 are associated with AF and aCHF. This decrease may result from a higher consumption of TGF-beta 1 within the impaired myocardium or antifibrotic functions of natriuretic peptides.
Clin Res Cardiol (2011) 100:335–342 DOI 10.1007/s00392-010-0248-1 Received: 30 May 2010 / Accepted: 20 October 2010 / Published online: 11 November 2010
