Role of Dendritic Cells in Atopic Dermatitis: An Update
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Thomas Bieber & Natalija Novak & Nadine Herrman & Susanne Koch
- چاپ و سال / کشور: 2010
Description
Dendritic cells (DCs) have been recognized as key players bridging innate and adaptive immune systems. They control the balance of the adaptive immune response, and the functional behavior of DCs is mainly dictated by their microenvironment. Atopic dermatitis (AD) is a paradigmatic disease where the inflammatory microenvironment has a deep impact on DCs. The emergence of IgE-mediated sensitization is tightly related to the impact of locally released cytokines by either keratinocytes, T cells, or other cells involved in the inflammatory reaction. This review will focus on the recent and relevant findings in the field of immunobiology of DCs and their role in AD.
Clinic Rev Allerg Immuno Springer Science+Business Media, LLC 2010
