Cholinergic system of rats treated with vincristine sulphate and nandrolone decanoate
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Danieli B. Martins & Cinthia M. Mazzanti & Roselia Spanevello & Roberta Schmatz & Maísa Corrêa & Naiara Stefanello & Vera Morsch & Angela P. M. Veiga
- چاپ و سال / کشور: 2010
Description
This study aimed to detect brain and red blood cell acetylcholinesterase activity (AChE and RBC-AChE, respectively) of rats treated with vincristine sulphate and different doses of nandrolone decanoate. Thirty rats were divided into six groups (n=5). The treatments were applied once a week for 2 weeks. Sample collection was performed in the third week. The groups were divided in: G1, physiologic solution (PS) (first and second week); G2, vincristine sulphate (4 mg/m2) in the first week and PS in the second week; G3, PS in the first week and nandrolone decanoate (1.8 mg/kg-1) in the second week; G4, PS in the first week and nandrolone decanoate (10 mg/kg-1) in the second week; G5, vincristine sulphate (4 mg/m2) in the first week and nandrolone decanoate (1.8 mg/kg-1) in the second week; and G6, vincristine sulphate (4 mg/m2) in the first week and nandrolone decanoate (10 mg/kg-1) in the second week. The isolated use of nandrolone decanoate and its use in association with vincristine sulphate altered brain AChE and RBC-AChE activity. These results suggest that there is interference in cholinergic neurotransmission, which could cause an alteration of its neurotransmitter, as well as a low or high stimulation of post-synaptic receptors. The serum RBC-AChE activity results presented in this study are similar to those exhibited by brain tissue.
Comp Clin Pathol (2011) 20:33–37 DOI 10.1007/s00580-009-0948-y Received: 19 September 2009 / Accepted: 1 December 2009 / Published online: 8 January 2010
