Reactivation of latent Toxoplasma gondii in immunocompromised cancer patients
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Mohamad Nidal Khabaz & Layla Elkhateeb & Jamil Al-Alami
- چاپ و سال / کشور: 2010
Description
Active Toxoplasma gondii infection in cancer patients undergoing anticancer chemotherapy was evaluated using both enzyme-linked immunosorbent assay (ELISA) and polymerase chain reaction (PCR) techniques. Ninetynine cancer patients were studied. Sixty seven of those patients were under cancer chemotherapy treatment, 41 (61.2%) of which were found to be ELISA immunoglobulin g (IgG) positive and five (7.5%) were PCR positive. On the other hand, none of the 32 untreated cancer patients was found to be PCR positive although 22 (68.7%) of them were ELISA IgG positive. These findings suggest the possibility that treatment with immunosuppressive agents predisposed cancer patients to reactivation of T. gondii infection.
Comp Clin Pathol (2011) 20:183–186 DOI 10.1007/s00580-010-0975-8 Received: 15 December 2009 / Accepted: 4 February 2010 / Published online: 2 March 2010
