Evaluation of sialic acids, TNF-á, INF-ã, and acute-phase proteins in cattle infected with foot-and-mouth disease
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Saeed Nazifi & Maryam Ansari-Lari & Narjes Ghafari & Somayeh Mohtarami & Amir Ghezelbash & Mohammad Reza Tabandeh
- چاپ و سال / کشور: 2010
Description
The present study was conducted to evaluate the concentrations of sialic acids, tumor necrosis factor-alpha (TNF-á), and gamma-interferon (INF-ã) and their correlation with acute-phase proteins (haptoglobin, serum amyloid A, ceruloplasmin, and fibrinogen) in cattle infected with foot-and-mouth disease (FMD). Thirty cows were diagnosed and confirmed for FMD. Ten clinically healthy adult cattle were selected as a control group. Serum haptoglobin (Hp), serum amyloid A (SAA), ceruloplasmin, fibrinogen, total sialic acid (TSA), lipid-bound sialic acid (LBSA), protein-bound sialic acid (PBSA), TNF-á, and INF-ã were measured by validated standard methods. All parameters were significantly higher in the diseased animals compared with the healthy group (P<0.001 in all cases). There were significant associations between Hp and INF-ã, fibrinogen with TSA, fibrinogen with PBSA, TSA with PBSA, and TNF-á with ceruloplasmin in the control group. In the FMD group, significant associations were observed for PBSA with TSA, PBSA with LBSA, and TNF-á with ceruloplasmin. The results of this study revealed that inflammatory mediators (TNF-á, INF-ã, and sialic acids) and acute-phase proteins (SAA, Hp, ceruloplasmin, and fibrinogen) concentrations increased in FMD-infected cattle in response to viral infection. However, more detailed future studies are required to characterize such responses and to improve the development of novel control strategies against FMD.
Comp Clin Pathol DOI 10.1007/s00580-010-1059-5 Received: 26 February 2010 / Accepted: 24 June 2010
