New Therapeutics in C1INH Deficiency: A Review of Recent Studies and Advances
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Neil Parikh & Marc A. Riedl
- چاپ و سال / کشور: 2011
Description
Hereditary angioedema (HAE) is a genetic condition causing a significant burden of illness for affected individuals. Episodes of angioedema involving the skin, gastrointestinal tract, as well as the larynx and oropharynx are often unpredictable and cause significant morbidity and mortality. Isolation of the underlying protein deficiency, specifically the serine protease C1 inhibitor, and further description of its role in multiple physiologic cascades has led to the development of several specific therapies for HAE. This report provides a brief overview of HAE but focuses primarily on reviewing recently published clinical studies of therapeutics developed for medical management of the condition.
Curr Allergy Asthma Rep (2011) 11:300–308 DOI 10.1007/s11882-011-0203-x Published online: 24 May 2011
