The Potential Role of Interleukin-17 in Severe Asthma
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Yui-Hsi Wang & Marsha Wills-Karp
- چاپ و سال / کشور: 2011
Description
Asthma has long been characterized as a disease of dysregulated T-helper type 2 immune responses to environmental allergens. Clinical studies suggest that asthma is a heterogeneous disorder with distinct types of inflammatory processes. Accumulating evidence suggests that aberrant interleukin (IL)-17 production is a key determinant of severe forms of asthma. However, the identity of IL-17–producing cells and the factors regulating IL-17 production during the course of allergic inflammation remain elusive. In this review, we summarize the potential IL-17–producing cells and their involvement in the inflammatory responses that mediate distinct features of asthma. The role of proinflammatory cytokines and the complement pathway in regulating the generation of IL-17–producing T cells is also discussed. Understanding the biology of IL-17 in the context of allergic inflammation may be informative in the development of novel approaches to the diagnosis and treatment of asthma.
Curr Allergy Asthma Rep DOI 10.1007/s11882-011-0210-y Springer Science+Business Media, LLC 2011
