Genome-Wide Association Studies in Atherosclerosis
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : S. Sivapalaratnam & M. M. Motazacker & S. Maiwald & G. K. Hovingh & J. J. P. Kastelein & M. Levi & M. D. Trip & G. M. Dallinga-Thie
- چاپ و سال / کشور: 2011
Description
Cardiovascular disease remains the major cause of worldwide morbidity and mortality. Its pathophysiology is complex and multifactorial. Because the phenotype of cardiovascular disease often shows a marked heritable pattern, it is likely that genetic factors play an important role. In recent years, large genome-wide association studies have been conducted to decipher the molecular mechanisms underlying this heritable and prevalent phenotype. The emphasis of this review is on the recently identified 17 susceptibility loci for coronary artery disease. Implications of their discovery for biology and clinical medicine are discussed. A description of the landscape of human genetics in the near future in the context of nextgeneration sequence technologies is provided at the conclusion of this review.
Curr Atheroscler Rep (2011) 13:225–232 DOI 10.1007/s11883-011-0173-4 Published online: 3 March 2011
