The High-Risk Plaque Initiative: Primary Prevention of Atherothrombotic Events in the Asymptomatic Population
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Erling Falk & Henrik Sillesen & Pieter Muntendam & Valentin Fuster
- چاپ و سال / کشور: 2011
Description
The High-Risk Plaque (HRP) Initiative is a research and development effort to advance the understanding, recognition, and management of asymptomatic individuals at risk for a near-term atherothrombotic event such as myocardial infarction or stroke. Clinical studies using the newest technologies have been initiated, including the BioImage Study in which novel approaches are tested in a typical health plan population. Asymptomatic at-risk individuals were enrolled, including a survey-only group (n=865), a group undergoing traditional risk factor scoring (n=718), and a group in which all were assessed for both risk factors and subclinical atherosclerosis (n=6104). The latter two groups underwent baseline examination in a dedicated mobile facility equipped with advanced imaging tools suitable for noninvasive screening for subclinical atherosclerosis (coronary artery calcium by computed tomography [CT], carotid and aortic disease by ultrasound, and ankle-brachial index). Selected participants were offered advanced imaging (contrast-enhanced CT, magnetic resonance imaging, and positron emission tomography/CT). Plasma, PAXgene RNA, and DNA samples were obtained for biomarker discovery studies. All individuals will be followed until 600 major atherothrombotic events have occurred in those undergoing imaging.
Curr Atheroscler Rep DOI 10.1007/s11883-011-0193-0
