Cryoablation as a Replacement for Surgical Resection in Early Stage Breast Cancer
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Michael S. Sabel
- چاپ و سال / کشور: 2011
Description
With improvements in technology, freezing malignant tissue (cryoablation) as an alternative to surgery has been used to treat cancers of the skin, prostate, liver, lung, and bone. There is significant interest in cryoablation of breast cancer. Potential advantages over lumpectomy include the minimally invasive nature of the treatment, improved cosmetic results, patient comfort, decreased costs, and the possible immune response to the ablated tissue. Several pre-clinical and clinical studies have demonstrated both the feasibility of breast cancer cryoablation and the generation of an anti-tumor immune response, and clinical experience with cryoablation of benign breast tumors is growing. The ongoing American College of Surgeons Oncology Group Trial Z1072, a phase II trial examining the success of breast cancer cryoablation, is an important first step in possibly replacing lumpectomy with cryoablation for a subset of breast cancer patients. This article reviews the breast cryoablation literature to date and discusses the directions the field needs to move in to realize that goal.
Curr Breast Cancer Rep (2011) 3:109–116 DOI 10.1007/s12609-011-0044-6 Published online: 5 April 2011
