Heart Failure Pharmacogenetics: Past, Present, and Future
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Heather M. Davis & Julie A. Johnson
- چاپ و سال / کشور: 2011
Description
Heart failure is an increasingly common disease associated with significant morbidity and mortality in the aging population. Recent advances in heart failure pharmacotherapy have established several agents as beneficial to disease progression and outcomes. However, current consensus guideline-recommended pharmacotherapy may not represent an optimal treatment strategy in all heart failure patients. Specifically, individuals with genetic variation in regions central to mediation of beneficial response to standard heart failure agents may not receive optimal benefit from these drugs. Additionally, targeted approaches in phase 3 clinical trials that select patients for inclusion based on the genotype most likely to respond might advance the currently stalled drug development pipeline in heart failure. This article reviews the literature in heart failure pharmacogenetics to date, opportunities for discovery in recent and upcoming clinical trials, as well as future directions in this field.
Curr Cardiol Rep (2011) 13:175–184 DOI 10.1007/s11886-011-0181-6 Published online: 18 March 2011
