Antifungal Pharmacokinetics and Dosing Considerations in Burn Patients
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Carla J. Walraven & Renée-Claude Mercier & Samuel A. Lee
- چاپ و سال / کشور: 2011
Description
Patients with burn injuries are at high risk of developing invasive fungal infections leading to increased morbidity and mortality. Burn patients undergo major physiologic changes, which produce significant alterations in the pharmacokinetics and pharmacodynamics of antimicrobial agents. These changes result from the breakdown of the body’s natural barriers to infection and the systemic responses that subsequently ensue after burn injury, including systemic inflammatory responses, third spacing, and development of a hypermetabolic state. Severe burn injuries often lead to larger volumes of distribution and increased drug clearance. Limited data are available to guide the clinician in optimizing the dosing regimen of antifungals in patients with burn injuries. We present a review of antifungal pharmacokinetics and describe how these properties can be used to design rational therapeutic regimens tailored to the pharmacodynamic alterations characteristic of burn patients.
Curr Fungal Infect Rep (2011) 5:67–74 DOI 10.1007/s12281-011-0047-9 Published online: 11 February 2011
