Update on Antifungal Drug Dosing and Therapeutic Drug Monitoring
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Steven Trifilio
- چاپ و سال / کشور: 2011
Description
The prevention and treatment of invasive fungal infections can be compromised by antifungal agents that display unpredictable pharmacokinetics and significant drug interactions and which demonstrate a strong relationship between drug exposure and efficacy and toxicity. Clinical studies have shown that maintaining antifungal drug levels within a targeted range decreases the risk for treatment failure and drug toxicity and thus have established a role for therapeutic drug monitoring with the use of various agents. Evidence from experimental and clinical studies supporting the role of therapeutic drug monitoring and practical applications for attaining targeted levels are reviewed.
Curr Fungal Infect Rep (2011) 5:92–102 DOI 10.1007/s12281-011-0050-1 Published online: 5 April 2011
