Invasive Candidiasis in the Neutropenic Cancer Patient
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Maria N. Gamaletsou & Nikolaos V. Sipsas & Dimitrios P. Kontoyiannis
- چاپ و سال / کشور: 2010
Description
Invasive candidiasis (IC) is an important complication among cancer patients with neutropenia, as it is associated with significant mortality. Despite the introduction of the new antifungals in clinical practice and their widespread use as treatment or prophylaxis, the incidence of IC and the predominance of non-albicans Candida species remain unchanged, and mortality rates remain as high as in previous periods. New techniques have been developed to decrease the time to Candida species identification from blood cultures. Nonculture diagnostic methods and molecular diagnostic tests for detection of Candida are promising but have not been validated in neutropenic patients. Recently, voriconazole was proved to be as effective as fluconazole for prophylaxis in neutropenic recipients of hematopoietic stem cell transplants and in patients with graft-versus-host disease. Despite the lack of randomized studies of the treatment of IC among neutropenic patients, it seems that the success rates of antifungal therapy do not differ from those in nonneutropenic patients
Curr Fungal Infect Rep (2011) 5:34–41 DOI 10.1007/s12281-010-0044-4 Published online: 22 December 2010
