New Perspectives in cAMP-Signaling Modulation
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Magali Berthouze & Anne-Coline Laurent & Magali Breckler & Frank Lezoualc’h
- چاپ و سال / کشور: 2011
Description
Cyclic adenosine 3پŒ,5پŒ-monophosphate (cAMP) mediates the biological effects of various hormones and neurotransmitters. Stimulation of cardiac ƒہ-adrenergic receptors (ƒہ-AR) via catecholamines leads to activation of adenylyl cyclases and increases cAMP production to enhance myocardial function. Because many other receptors signaling through cAMPgeneration exist in cardiac myocytes, a central question is how different hormones induce distinct cellular responses through the same second messenger. A large body of evidence suggests that the localization and compartmentalization of ƒہ- AR/cAMP signaling affects the net outcome of biological functions. Spatiotemporal dynamics of cAMP action is achieved by various proteins, including protein kinase A (PKA), phosphodiesterases, and scaffolding proteins such as A-kinase.anchoring proteins. In addition, the discovery of the cAMP target Epac (exchange proteins directly activated by cAMP), which functions in a PKA-independent manner, represents a novel mechanism for governing cAMP-signaling specificity. Aberrant cAMP signaling through dysregulation of ƒہ-AR/cAMP compartmentalization may contribute to cardiac remodeling and heart failure.
Curr Heart Fail Rep (2011) 8:159–167 DOI 10.1007/s11897-011-0062-8 Published online: 20 May 2011
