New Drugs for Chronic Myelogenous Leukemia
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Fabio P. S. Santos & Alfonso Quintلs-Cardama
- چاپ و سال / کشور: 2011
Description
The introduction of tyrosine kinase inhibitors (TKIs) has changed the landscape of therapy for chronic myelogenous leukemia (CML). Once considered an incurable malignancy, CML now has become a manageable chronic condition. Despite the great advances that imatinib has brought to the treatment of CML, some patients still develop resistance to imatinib and other TKIs, such as dasatinib and nilotinib. Furthermore, none of the clinically available TKIs is capable of eradicating leukemia stem cells and therefore curing CML. Several new compounds have been developed in recent years in an attempt to manage TKI-resistant CML. These include third-generation TKIs (ponatinib, danusertib) and even old compounds such as omacetaxine, which were developed before imatinib and now find a possible niche in the treatment of imatinibresistant CML. We review the current preclinical and clinical data on the most promising new compounds for the treatment of CML.
Curr Hematol Malig Rep (2011) 6:96–103 DOI 10.1007/s11899-011-0079-9 Published online: 16 February 2011
