IL28B: Implications for Therapy
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Arjmand R. Mufti & Nancy Reau
- چاپ و سال / کشور: 2011
Description
Within the last 2 years, a number of Genome- Wide Association Studies (GWAS) have shown that single nucleotide polymorphisms (SNPs) in the interleukin 28B (IL28B) gene region, encoding interferon-ƒة3, are predictive of hepatitis C clearance in patients receiving interferon-ƒ؟ and ribavirin-based treatment regimens. In addition, the same SNPs are strongly linked with spontaneous clearance of hepatitis C virus in treatment-naive patients. The causal variant responsible for these findings has not been identified. Nevertheless, the discovery of a correlation between the IL28B genotype status and treatment outcome has impacted all aspects of clinical decision making in patients with hepatitis C, and has opened up the very real possibility of individualized treatment regimens based on variations at the IL28B gene locus.
Curr Hepatitis Rep (2011) 10:153–161 DOI 10.1007/s11901-011-0099-x Published online: 15 June 2011
