Treatment of Myasthenia Gravis
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Vikas Kumar & Henry J. Kaminski
- چاپ و سال / کشور: 2010
Description
Myasthenia gravis (MG) is an antibodymediated, neuromuscular transmission disorder, which ranges in clinical manifestations of ocular myasthenia that may be visually disabling to myasthenic crisis with patients suffering life-threatening respiratory insufficiency. MG also has pathophysiologic subgroups based on presence or absence of acetylcholine receptor or muscle-specific kinase antibodies and presence of thymoma. Cholinesterase inhibitors partially improve weakness, but the vast majority of patients require therapies that moderate the autoimmune attack. Mortality of MG has been reduced over the last century, but adverse effects of treatment compromise patient care and rigorous evidence to guide the clinician are lacking.
Curr Neurol Neurosci Rep (2011) 11:89–96 DOI 10.1007/s11910-010-0151-1 Published online: 7 October 2010
