Medical Treatment of Mesothelioma: Anything New?
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Nagio Takigawa & Katsuyuki Kiura & Takumi Kishimoto
- چاپ و سال / کشور: 2011
Description
In the present report, we review the current standard and investigational treatments of malignant pleural mesothelioma (MPM). Several studies have reported the use of gemcitabine and cisplatin as an induction chemotherapy in combination with extrapleural pneumonectomy (EPP) and thoracic radiation in a combined-modality approach for resectable MPM. Since the combination of cisplatin with pemetrexed was applied as the standard firstline regimen for unresectable MPM, the combination as an induction chemotherapy regimen has been proven effective in phase 2 trials. In addition, intensity-modulated radiation therapy and proton therapy have been introduced as new radiation methods into the combined modality. Hyperthermic intraoperative chemotherapy following EPP appears effective with acceptable toxicity. In addition, clinical studies that include molecular targeting agents, immunotherapy, and gene therapy have all been conducted. Thus, although there are numerous hopeful treatments for MPM, the benefits of these regimens remain to be proven in a randomized clinical setting
Curr Oncol Rep (2011) 13:265–271 DOI 10.1007/s11912-011-0172-1 Published online: 19 April 2011
