Synovitis in Psoriatic Arthritis: Immunohistochemistry,Comparisons With Rheumatoid Arthritis, and Effects of Therapy
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Arno W. R. van Kuijk & Paul P. Tak
- چاپ و سال / کشور: 2011
Description
Psoriatic arthritis (PsA) is a chronic inflammatory arthropathy associatedwith psoriasis that affects the peripheral joints, spine, and entheses. Most patients with PsA present with peripheral synovitis of the oligoarticular or polyarticular subtype. As one of the targets of this disease, studies on the synovium may provide insight into the mechanisms involved in this condition. Key findings from the available studies comparing synovial tissue of PsA and rheumatoid arthritis patients are discussed in this review. Also, changes in the synovial infiltrate, expression of proinflammatory cytokines and adhesion molecules, and vascularity in synovial tissue after treatment with various medications are addressed. Finally, a model for proof-of-principle study design using serial synovial biopsies is described, which could be used to predict clinical (in)efficacy in early clinical trial design in PsA.
Curr Rheumatol Rep (2011) 13:353–359 DOI 10.1007/s11926-011-0181-y Published online: 19 April 2011
