Gut-Brain Chemokine Changes in Portal Hypertensive Rats
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Joaquin Merino Maria-Angeles Aller Sandra Rubio Natalia Arias Maria-Paz Nava Maria Loscertales Jaime Arias Jorge-Luis Arias
- چاپ و سال / کشور: 2011
Description
Background Hepatic encephalopathy is a syndrome whose physiopathology is poorly understood; therefore, current diagnostic tests are imperfect and modern therapy is nonspecific. Particularly, it has been suggested that inflammation plays an important role in the pathogenesis of portal hypertensive encephalopathy in the rat. Aim We have studied an experimental model of portal hypertension based on a triple partial portal vein ligation in the rat to verify this hypothesis. Methods One month after portal hypertension we assayed in the splanchnic area (liver, small bowel and mesenteric lymph nodes) and in the central nervous system (hippocampus and cerebellum) fractalkine (CX3CL1) and stromal cell-derived factor alpha (SDF1-a) as well as their respective receptors (CX3CR1 and CXCR4) because of their key role in inflammatory processes. Results The significant increase of fractalkine in mesenteric lymph nodes (P\0.05) and its receptor (CX3CR1) in the small bowel (P\0.05) and hippocampus (P\0.01), associated with the increased expression of SDF1-a in the hippocampus (P\0.01) and the cerebellum (P\0.01) suggest that prehepatic portal hypertension in the rat induces important alterations in the expression of chemokines in the gut-brain axis. Conclusion The present study revealed that portal hypertension is associated with splanchnic-braininflammatory alterations mediated by chemokines.
Dig Dis Sci (2011) 56:2309–2317 DOI 10.1007/s10620-011-1625-y Received: 28 October 2010 / Accepted: 7 February 2011 / Published online: 24 February 2011
