ORIGINAL ARTICLE Fundic Gland Polyps and Association with Proton Pump Inhibitor Intake: A Prospective Study in 1,780 Endoscopies
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Adriana Zelter Jose´ Luis Ferna´ndez Claudio Bilder Pablo Rodrı´guez Andre´s Wonaga Fernanda Dorado Miriam Galich Luis Alberto Viola
- چاپ و سال / کشور: 2010
Description
Background and Aims Fundic gland polyps (FGPs) are incidentally found when an endoscopy is performed for a non-related indication. Some authors suggested a relationship with proton pump inhibitor (PPI) intake. We aimed to determine their prevalence and association with PPI intake. Methods We prospectively studied 1,780 patients who underwent a gastroduodenal endoscopy at our ambulatory care center between June 2007 and August 2008. PPI intake during a period of at least 12 months, female gender and age were statistically evaluated as risk factors for the presence of FGPs. Then, a multiple logistic regression analysis was applied to these variables. Results Gastric polyps were found in 129 patients (7.2%) and 77 (4.33%) were FGPs. Five patients with no available histology were excluded for the assessment of risk factors. PPI intake was detected in 49 patients with FGPs (63.6%) and 264 without FGPs (15.5%) (P\0.0001). Fifty-nine patients with FGPs (76.7%) and 987 without FGPs (58.1%) were women (P\0.001). The mean age was 58.91 ± 11.82 years in patients with FGPs and 50.34 ± 15.04 years in patients without FGPs (P\0.0001). The three variables remained significant in the multiple model: PPI intake: P\0.0001, OR 9.00 (95% CI 5.44–14.89); female gender: P = 0.0001, OR 2.95 (95% CI 1.69–5.15); age: P = 0.001, OR 1.03 (95% CI 1.01–1.05). Conclusions In our population, the prevalence of FGPs was high. Although female gender and age were also significant, PPI intake was the strongest risk factor associated with the presence of FGPs.
Dig Dis Sci (2011) 56:1743–1748 DOI 10.1007/s10620-010-1493-x Received: 16 June 2010 / Accepted: 10 November 2010 / Published online: 3 December 2010
