Fecal Calprotectin Is a Useful Marker for Disease Activity in Pediatric Patients with Inflammatory Bowel Disease
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Tomoki Aomatsu Atsushi Yoden Kyoichi Matsumoto Emi Kimura Keisuke Inoue Akira Andoh Hiroshi Tamai
- چاپ و سال / کشور: 2011
Description
Background Studies evaluating the correlation between endoscopic disease activity and noninvasive markers are scarce in inflammatory bowel disease (IBD). Aim The aim of this study is to evaluate the accuracy of the fecal calprotectin (FC) assay as a marker of disease activity of IBD, as determined by an extensive endoscopic scoring system. Methods Thirty-five children and adolescents with IBD [17 with ulcerative colitis (UC) and 18 with Crohn’s disease (CD)] and 28 healthy volunteers were enrolled. FC levels were determined by ELISA. The sum of Matts’ score for UC and the simple endoscopic score for Crohn’s disease (SES-CD) were used. The ileal lesions were evaluated by ultrasonography. Results In UC patients, there was a strong correlation between FC levels and the sum of Matts’ score (r = 0.838, p\0.01). FC levels were significantly elevated in endoscopically active patients (median 1,562.5 lg/g) as compared to patients in endoscopic remission (median 38.9 lg/g) or healthy controls (median 19.9 lg/g). In CD patients, there was a strong correlation between FC levels and the SES-CD score (r = 0.760, p\0.01). The FC levels were significantly higher in endoscopically active patients (median 2,037.5 lg/g) than in endoscopically inactive patients (median 172.5 lg/g) or healthy controls (median 19.9 lg/g), respectively. The FC levels of patients with ileal wall thickening (median 2,225.0 lg/g) were significantly higher than healthy controls (median 19.9 lg/g) and patients lacking ileal wall thickening (median 17.5 lg/g), respectively. Conclusions The FC assay is a useful marker for the detection of mucosal inflammation in pediatric IBD patients
Dig Dis Sci (2011) 56:2372–2377 DOI 10.1007/s10620-011-1633-y Received: 30 August 2010 / Accepted: 14 February 2011 / Published online: 11 March 2011
