Quantitative Assessment of Endoscopic Images for Degree of Villous Atrophy in Celiac Disease
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Edward J. Ciaccio Govind Bhagat Christina A. Tennyson Suzanne K. Lewis Lincoln Hernandez Peter H. R. Green
- چاپ و سال / کشور: 2010
Description
Background The degree of villous atrophy in celiac disease is difficult to assess at endoscopy. We sought to develop a quantitative technique for the evaluation of villous atrophy in endoscopic images. Method In ten celiac patients as identified by standard endoscopy with biopsy, and ten control patients, standard and videocapsule endoscopic images of the duodenum were digitized. Subimages 7.5 9 7.5 mm2 in area from random locations within each image were assessed by measuring the length of mucosal fissures per unit area (L), and correlating L with the histologic grade of villous atrophy as determined by modified Marsh criteria. Results Mean L values for standard endoscopic images were 37.8, 43.3, 64.1, and 83.5 mm for Marsh grades II, IIIa, IIIb, and IIIc, respectively. Mean L values for videocapsule images were 49.1, 50.0, 64.7, and 72.4 mm for Marsh grades II, IIIa, IIIb, and IIIc, respectively. Significant differences in the means existed between celiac images (Marsh scores II-IIIc) versus controls (p\0.001) for both endoscopic and videocapsule images. There were no significant differences between measurements obtained from endoscopic versus videocapsule images. Conclusions Quantified image analysis correlates with the histologic grade of villous atrophy, is automated, and lacks observer bias, thus lending itself to standardization
Dig Dis Sci (2011) 56:805–811 DOI 10.1007/s10620-010-1371-6 Received: 10 June 2010 / Accepted: 26 July 2010 / Published online: 16 September 2010
