CT Portography with Gastric Variceal Volume Measurements in the Evaluation of Endoscopic Therapeutic Efficacy of Tissue Adhesive Injection into Gastric Varices: A Pilot Study
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : John P. Rice Meghan Lubner Andrew Taylor Bret J. Spier Adnan Said Michael R. Lucey Alexandru Musat Mark Reichelderfer Patrick R. Pfa
- چاپ و سال / کشور: 2011
Description
Background N-butyl-2-cyanoacrylate (NBCA) injection is used for treating gastric varices (GV). Determining the degree of obliteration of GV is not readily evident at endoscopy. Aims The aim of this study was to evaluate CT portography with gastric variceal volume calculations to assess endoscopic therapeutic efficacy of NBCA injection. Methods The study design is a retrospective series pilot study. The setting is a single, tertiary care academic medical center. Ten patients underwent esophagogastroduodenoscopy (EGD)withNBCAinjection ofGVand had biphasicCTscans performed before and after injection therapy. Based on portal venous images, 3D reconstruction and semi-automated volume calculations of GV were performed. Pre and post injection GV volume calculations were compared. Results The mean pre-procedure GV volume was 89.84 cm3. Eight patients had significant improvement in GV volume from pre-treatment versus post-treatment (95.65 cm3 vs. 49.65 cm3, P-value 0.04). Pre-procedure GV volume was not significantly different in patients treated for active hemorrhage versus no hemorrhage (101.66 cm3 vs. 72.11 cm3, P-value 0.33).Two patients had a subsequentGVhemorrhage after NBCA injection. The mean residualGV volume in these patients versus those that did not re-bleed was significantly more (127.77 cm3 vs. 38.00 cm3, P-value 0.005). Conclusions CT portography with measurement of GV volume is a potentially useful tool in determining the therapeutic efficacy NBCA injection of GV. Patients with higher residual GV volumes are at increased risk of hemorrhage and may benefit from repeat injection to reach ideal GV volumes.
Dig Dis Sci (2011) 56:2466–2472 DOI 10.1007/s10620-011-1616-z Received: 30 November 2010 / Accepted: 31 January 2011 / Published online: 19 February 2011
