Impact of Preexisting Diabetes Mellitus on Outcome After Liver Transplantation in Patients with Hepatitis B Virus-Related Liver Disease
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Qi Ling Xiao Xu Qiang Wei Xuyong Wei Zhuoyi Wang Lin Zhou Shusen Zheng
- چاپ و سال / کشور: 2010
Description
Background Preexisting diabetes mellitus (DM) has been reported to have an adverse consequence on patient prognosis after liver transplantation in the West. So far, there are few reports on the effect of preexisting DM on outcome of liver transplant recipients with HBV infection. Aims We aimed to examine the impact of preexisting DM on post-transplant outcome in Chinese patients with HBVrelated liver disease. Methods The post-transplant morbidities and patient survival were compared between 48 diabetes patients (DM group) and 96 non-diabetes patients (control group) matched for age, gender, primary disease and model for endstage liver diseases score. The DM group was further divided into hyperglycemia patients (fasting blood glucose[ 8.0 mmol/L, n = 22) and non-hyperglycemia patients (fasting blood glucose B8.0 mmol/L, n = 26). Results Patient characteristics were comparable between both groups, except a higher incidence of hepatic encephalopathy in the DM group than that in the control group (22.9% vs. 10.4%, P = 0.045). The incidences of posttransplant complications and patient survival did not differ significantly between the DM and control groups, or between non-hyperglycemia patients and their matched case controls. Hyperglycemia patients showed a higher incidence of post-transplant sepsis (18.2% vs. 2.3%, P = 0.039) and biliary complications (31.8% vs. 6.8%, P = 0.012) than their matched case controls. Conclusions Preexisting DM is not a contraindication for liver transplantation in patients with HBV-related liver disease. A tight control of blood glucose to a level of B8.0 mmol/L was necessary to reduce the risk of complications after liver transplantation
Dig Dis Sci (2011) 56:889–893 DOI 10.1007/s10620-010-1358-3 Received: 14 June 2010 / Accepted: 14 July 2010 / Published online: 12 August 2010
