Prevalence of Autoimmune Liver Disease Related Autoantibodies in Chinese Patients with Primary Biliary Cirrhosis
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Chaojun Hu Chuiwen Deng Guang Song Wen Zhang Shulan Zhang Xi Li Ping Li Fengchun Zhang Yongzhe Li
- چاپ و سال / کشور: 2011
Description
Background The prevalence of autoimmune liver disease (AiLD)-related autoantibodies has not been defined in Chinese patients with primary biliary cirrhosis (PBC) and therefore needs to be characterized. Aims The purpose of this study was to explore the prevalence of AiLD-related autoantibodies in Chinese patients with PBC. Methods Indirect immunofluorescence was used to detect anti-mitochondrial antibodies (AMA) in the sera from 198 PBC, 44 autoimmune hepatitis (AIH) and 41 non-autoimmune liver disease controls (LDC). ELISA assays were used to test the presence of anti-M2, anti-gp210, anti-sp100, anti- SLA, anti-LC1 and anti-LKM-1 antibodies. Results AMA was present in 92.4, 15.9 and 7.3%, respectively, of patients with PBC, AIH and LDC. Anti-M2 was present in 87.4% of the PBC patients, but only in 4.5 and 4.9%, respectively, of AIH and LDC patients. Anti-gp210 and anti-sp100 were detected in 34.3 and 25.8% of PBC, 6.8 and 15.9% of AIH and in 4.9 and 17.1% of LDC patients. Anti-LC1, anti-SLA and anti-LKM-1 were, respectively, present in 1.5, 0.0 and 0.5% of PBC, and 9.1, 11.4 and 2.3% of AIH, and none of LDC. PBC patients that were AMApositive presented with higher IgM levels but lower CRP levels than negative ones. ALT, TBIL, DBIL, GGT, ALP, and AST were detected at higher levels and ALB at lower levels in PBC positive for anti-gp210 (P\0.05). Conclusions The prevalence of AiLD-related autoantibodies we provided might help define PBC in China. Antisp100 is not a better prognostic marker for Chinese PBC patients compared to anti-gp210. The identification of effective diagnostic biomarkers for AMA-negative PBC patients is still needed
Dig Dis Sci DOI 10.1007/s10620-011-1756-1 Received: 14 March 2011 / Accepted: 12 May 2011
