Transient leukoencephalopathy after intrathecal methotrexate mimicking stroke
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Amit Agarwal & Kanupriya Vijay & Krishnamoorthy Thamburaj & Tao Ouyang
- چاپ و سال / کشور: 2010
Description
Methotrexate (MTX) is an indispensable antimetabolite for the treatment of oncological and immunological disorders in all age groups. It can be administrated intravenously as well as intrathecally and may be used alone or in combination with other drugs. Chronic leukoencephalopathy is a well-known side effect of MTX, especially in conjunction with intrathecal administration. However, acute neurotoxicity with confusion, disorientation, seizures, and focal deficits may also be seen. This can clinically mimic stroke with restricted diffusion on MRI. However, unlike stroke, there is resolution of clinical and imaging findings within 1–4 weeks. We report two cases of transient leukoencephalopathy following intrathecal methotrexate, with complete clinical and radiological resolutions on follow-up.
Emerg Radiol (2011) 18:345–347 DOI 10.1007/s10140-010-0931-6 Received: 28 November 2010 / Accepted: 20 December 2010 / Published online: 18 January 2011
